When young Lili is forced to give up her beloved dog, Hagen, because its mixed-breed heritage is deemed "unfit" by The State, she and the dog begin a dangerous journey back towards each other. At the same time, all the unwanted and so-called "unfit" dogs rise up under a new leader, Hagen, who has learned all too well in his journey through the streets and animal control centers how to bite the hand that beats him. After the dogs seize an opportunity to escape and revolt against mankind, courageous Lili may be the only person who can halt this unexpected war between man and dog.