The wheel of karma takes a hilarious spin when some unexpected magic permanently transforms Sam, a misogynistic playboy, into Samantha, a beautiful woman who must learn how to value females by being one herself. Soon Samantha is navigating the unfamiliar world of make-up, high heels and the same disrespectful male attention her former self was notorious for. But when she starts feeling more romance than bromance for her best bud, she wonders if hr new insight on life will help her master the feminine mystique or if she'll remain firmly planted in the friend zone.